Production of leukocyte inhibitory factor in response to concanavalin A was similar in the two groups, but those taking DMG tablets had a significantly higher mean response of leukocyte inhibition factor to streptokinase-streptodornase (P < 0.01) and to pneumococcal antigens after immunization with vaccine (P < 0.001). A double-blind study in 20 human volunteers showed a fourfold increase in antibody response to pneumococcal vaccine in those receiving DMG orally as compared with controls (P < 0.01). Its potential as an immunoadjuvant has also been suggested by a study of an analog of DMG, calcium pangamate.
Dimethylglycine (DMG), a tertiary amino acid, has had wide acceptance as a nonfuel nutrient presumably it enhances oxygen utilization by tissue and complexes free radicals.
